After that, the dose is raised to 0.5 mg weekly , which works as the maintenance dose for many users
Additionally, lifestyle factors play a significant role: weight gain, reduced physical activity, poor dietary adherence, or increased stress can all contribute to worsening glycaemic control, making it appear as though Rybelsus is no longer working
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In the SELECT trial, adverse events leading to permanent discontinuation were reported in 16.6% of semaglutide-treated participants versus 8.2% in the placebo group, which shows that persistence remains a meaningful clinical and commercial issue even in closely monitored study populations